Tudofovir 300 Tablet

Tudofovir 300 Tablet

650 INR/Bottle

Product Details:

  • Drug Type Other Types
  • Ingredients Each film coated tablet contains: Tenofovir Disoproxil Fumarate IP 300 mg Colours : Indigo Carmine & Titanium Dioxide. PHARMACOLOGY
  • Physical Form Tablets
  • Function Anti-Viral
  • Recommended For HIV infection Chronic hepatitis B virus (HBV) infection
  • Dosage 1 TABLETS DAILY
  • Dosage Guidelines AS PER DIOCTOR ADVICE
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Tudofovir 300 Tablet Price And Quantity

  • 650 INR/Bottle
  • 1 Bottle

Tudofovir 300 Tablet Product Specifications

  • Suitable For All
  • Each film coated tablet contains: Tenofovir Disoproxil Fumarate IP 300 mg Colours : Indigo Carmine & Titanium Dioxide. PHARMACOLOGY
  • Tablets
  • Other Types
  • Anti-Viral
  • HIV infection Chronic hepatitis B virus (HBV) infection
  • 30 Boxes

Tudofovir 300 Tablet Trade Information

  • Cash on Delivery (COD) Cash Advance (CA)
  • 500 Bottle Per Day
  • 2 Days
  • Contact us for information regarding our sample policy
  • 1*30
  • Asia
  • All India

Product Description

he pharmacokinetics of tenofovir disoproxil fumarate has been evaluated in healthy volunteers and HIV-1 infected individuals. Tenofovir pharmacokinetics is similar between these populations.

Absorption: Tenofovir disoproxil fumarate is a water soluble diester prodrug of the active ingredient tenofovir. The oral bioavailability of tenofovir from tenofovir disoproxil fumarate in fasted patients is approximately 25%. Following oral administration of a single dose of tenofovir disoproxil fumarate 300 mg to HIV-1 infected patients in the fasted state, maximum serum concentrations (C max ) are achieved in 1.0 0.4 hrs. C max and AUC values are 296 90 ng/mL and 2287 685 nghr/mL, respectively.

The pharmacokinetics of tenofovir are dose proportional over a tenofovir disoproxil fumarate dose range of 75 to 600 mg and are not affected by repeated dosing.

Effects of Food on Oral Absorption: Administration of tenofovir disoproxil fumarate following a high-fat meal (700 to 1000 kcal containing 40 to 50% fat) increases the oral bioavailability, with an increase in tenofovir AUC of approximately 40% and an increase in C max of approximately 14%. However, administration of tenofovir disoproxil fumarate with a light meal did not have a significant effect on the pharmacokinetics of tenofovir when compared to fasted administration of the drug. Food delays the time to tenofovir C max by approximately 1 hour.

Distribution: In vitro binding of tenofovir to human plasma or serum proteins is less than 0.7 and 7.2%, respectively, over the tenofovir concentration range 0.01 to 25 g/mL. The volume of distribution at steady state is 1.3 0.6 L/kg and 1.2 0.4 L/kg, following intravenous administration of tenofovir 1.0 mg/kg and 3.0 mg/kg.

Metabolism and Elimination: In vitro studies indicate that neither tenofovir disoproxil nor tenofovir are substrates of CYP450 enzymes.

Following IV administration of tenofovir, approximately 70-80% of the dose is recovered in the urine as unchanged tenofovir within 72 hours of dosing. Following single dose, oral administration of tenofovir disoproxil fumarate, the terminal elimination half-life of tenofovir is approximately 17 hours. After multiple oral doses of tenofovir disoproxil fumarate 300 mg once daily (under fed conditions), 32 10% of the administered dose is recovered in urine over 24 hours.

Tenofovir is eliminated by a combination of glomerular filtration and active tubular secretion.

INDICATIONS TUDOFOVIR is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.

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